Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen. Due to smoking and environmental pollution, incidences of lung cancer are rapidly increasing and so is the requirement of a reliable therapy option like sotorasib. Patients looking to Buy Sotorasib tablets online in India should always consult their oncologist and provide a valid prescription before initiating the procurement process.
What is Sotorasib (Lumakras) 120 mg?
- Generic name: Sotorasib
- Brand name: Lumakras
- Manufacturer: Amgen Inc.
- Drug class: Targeted KRAS G12C inhibitor
It is indicated in the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with the KRAS-G12C mutation in adults who have received at least one prior systemic therapy. It is also approved in combination with panitumumab for the treatment of adult patients with KRAS G12C-mutated mCRC as determined by an FDA approved-test, who have received prior fluorouracil-, oxaliplatin- and irinotecan-based chemotherapy. Sotorasib is a prescription only medicine and is not registered in India. Many patients search for options to Buy Sotorasib online in India when prescribed targeted therapy for KRAS G12C-mutated cancers.
How Does Sotorasib Work?
Usually, GTP binds to KRAS to allow downstream signalling through the MAP kinase pathway. GTP is hydrolyzed to GDP, and KRAS gets inactivated. However, KRAS G12C mutations impair hydrolysis of GTP and it remains in the active form. Sotorasib binds to the cysteine residue in KRAS G12C mutations, holding the protein in its inactive form. By this mechanism, it acts as a KRAS G12C inhibitor. Its target cysteine residue not present in the wild type KRAS, and this is great for avoiding off-target effects.
This mutation is present in 13% of non-small cell lung cancer, 3% of colorectal and appendix cancer, and 1-3% of solid tumors. This enables blocking and KRAS signaling, inhibits cell growth, and promotes apoptosis specifically in KRAS G12C tumor cell lines.
This product is an effective inhibitor of KRAS G12C, both- in vitro and in vivo with very less detectable off-target activity. In mouse tumor xenograft models, this treatment led to tumor regressions and prolonged survival. It was also associated with anti-tumor immunity in KRAS G12C models. To understand the role of KRAS G12C inhibition and the clinical significance of Lumakras therapy, read our detailed guide on Why Targeting KRAS Was Once Impossible and How Lumakras Proved the Doubters Wrong.
The growing demand for Sotorasib online in India reflects the increasing adoption of precision oncology treatments.
Availability of Lumakras 120 mg in India
Sotorasib, not being registered in India, is not readily available through local pharmacies or standard distribution networks. Since this is a prescription-only therapy, the price quotation for sotorasib is provided upon request, after submission of valid medical documents. For updated pricing and procurement details, contact us. Patients frequently inquire about the Sotorasib tablets price in India before proceeding with the import process.
Since the drug is not registered for commercial sale in India, the Sotorasib price in India may vary depending on –
- market dynamics
- supplier availability
- regulatory updates
- supplier
- origin country
- shipping and documentation
- GST/local taxes
- exchange rates
- changes in company pricing policies
For the latest Sotorasib 120 mg tablet price in India, patients are encouraged to contact our team directly for a personalized quotation. As pricing may vary based on supplier availability, import regulations, and other factors, reaching out to us ensures access to the most accurate and up-to-date information regarding Sotorasib price in India.
We help patients to access Sotorasib in India safely and legally, ensuring full regulatory compliance under the Named Patient Supply (NPS) program and providing assistance throughout the process—from document verification to final delivery. Patients looking for comprehensive information on pricing, availability, and access can also explore our dedicated article on Buy Sotorasib (Lumakras) 120 mg in India – Price & Access Guide.
Individuals seeking to Buy Sotorasib tablets in India can access the medicine through the Named Patient Supply route after submitting the required documents.
How to Access Sotorasib in India
As Sotorasib is not commercially registered in India, it is available only through the Named Patient Import Program (NPIP). We assist eligible patients in accessing Sotorasib in India through the Named Patient Supply (NPS) route, ensuring compliance with all applicable regulatory requirements. Patients with a valid prescription can buy Sotorasib 120 mg tablet in India through a legal and authorized import process, with end-to-end support for documentation, sourcing, and delivery. Sotorasib or Lumakras is available as 320 mg tablets in cartons containing one bottle of 90 tablets with child-resistant closure and as 120 mg tablets in cartons containing two bottles of 120 tablets or one bottle of 240 tablets with child-resistant closure.
Import process:
1. Request submission for your medicine
Patients or caregivers can send a request for the product by sharing prescription details and treatment requirements.
2. Submission of an application (Form 12A)
Submit an application in Form 12A, along with a valid prescription from a Registered Medical Practitioner (RMP).
3. Verification of documents
We verify the prescription and supporting medical documents to confirm eligibility for importing the drug in small quantities for personal medical use.
4. Permission to import
Once approval is granted by the Drugs Controller General (India), the process of importing medicines begins as per the prescription.
5. Sourcing the medicine
Our sourcing team connects with authorized global suppliers to find the best sotorasib price in India, thus making it convenient to easily access products like Sotorasib in India, and ensure authenticity before finalizing the offer.
Our team assists patients who wish to Buy Sotorasib tablets online in India by connecting them with authorized international suppliers.
6. Delivery of the medicine
After approval and confirmation, we coordinate logistics and ensure the safe, compliant, and timely delivery of the product to the patient’s location in India.
We help patients Buy Sotorasib online in India while ensuring quality assurance, authenticity, and regulatory compliance.
Documents Required for Procurement
To enable the product’s import to India, patients need to provide:
- A valid doctor’s prescription specifying the product name, dosage, treatment duration, and diagnosis.
- Recent medical history and test reports (preferably from the last three months), including those confirming disease.
- Government-issued ID proof and proof of residence of the patient.
- Import permit if applicable.
Accessing Sotorasib online in India requires the submission of valid medical records and a doctor’s prescription.
Dosage & Administration
Sotorasib is used as a single agent for KRAS G12C-mutated locally advanced or metastatic NSCLC, where the recommended dosage is 960 mg (three 320 mg tablets or four 240 mg tablets or eight 120 mg tablets) orally once daily until disease progression or unacceptable toxicity.
Sotorasib is also used in combination with panitumumab for KRAS G12C-mutated mCRC, and the recommended dosage is 960 mg (three 320 mg tablets or four 240 mg tablets or eight 120 mg tablets) orally once daily in combination with panitumumab until disease progression or unacceptable toxicity. Administer the first dose of Sotarasib prior to first panitumumab infusion. Before choosing to Buy Sotorasib tablets in India, patients should consult their treating physician regarding the appropriate dosage and understand the Sotorasib price in India and treatment requirements to plan their therapy effectively.
Possible Side Effects
There are no available data on Sotorasib use in pregnant women. Because of the potential for serious adverse reactions in breastfed children, women are advised not to breastfeed during treatment with sotorasib and for 1 week after the final dose. The safety and effectiveness of this product have not been established in pediatric patients. No overall differences in safety or effectiveness were observed between older patients and younger patients. No dosage modification is recommended in patients with mild to moderate hepatic impairment (Child Pugh A or B). The effect of severe hepatic impairment (Child-Pugh C) on the safety of Sotorasib is unknown. Monitor for sotorasib adverse reactions in patients with hepatic impairment more frequently since these patients may be at increased risk for adverse reactions including hepatotoxicity.
Conclusion
Patients searching to buy Lumakras tablet in India can obtain assistance through licensed import channels. Orders are finalized only after the submission of a valid prescription and the necessary supporting documents. Once the import permit is approved, the licensed supplier arranges the shipment of Lumakras from countries such as the USA, Canada, Europe, or Australia.
Through this process, patients can access and import Sotorasib in India safely and legally. We make these medicines available across major Indian cities and source them exclusively from genuine international suppliers to ensure safety, authenticity, and quality. We maintain complete transparency in pricing, and all prescriptions are reviewed and dispensed by registered pharmacists before delivery.
For patients interested in Buy Sotorasib tablets online in India, our team provides end-to-end support for legal importation, documentation, procurement, and timely delivery. For detailed information, availability, or pricing, patients can contact 247qualitymeds.com.
