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Human Cytomegalovirus Immunoglobulin (CMVIG)

Generic Name/API:Human Cytomegalovirus Immunoglobulin (CMVIG)
Packaging:One box containing: 1 vial with 10 ml (1,000 U) solution for infusion or 1 vial with 50 ml (5,000 U) solution for infusion
Storage:Store at 2° C – 8°C
Dosage:100-250mg/ kg IV evercy 2-3 weeks(Adjusted)
Strength:Vial of 50 ml and 10 ml
Indication:Megalotect Human Cytomegalovirus Immunoglobulin (CMVIG) is a high-titer, highly purified immunoglobulin product derived from human plasma. It is used as a prophylactic treatment for patients at high risk of developing Cytomegalovirus (CMV) infection or disease.
  • CMV Prophylaxis in solid or stem cell transplant. Treatment of CMV infections In CMV-seronegative recipients receiving CMV-seropositive organ transplants. In hematopoietic stem cell transplantation (HSCT).
  • Adjunctive therapy for CMV disease, especially in Immunocompromised Patients receiving antiviral therapy like ganciclovir

STRENGTH:

Vial of 50 ml and 10 ml

DOSAGE: 

100-250mg/ kg IV evercy 2-3 weeks(Adjusted)

ADVERSE EFFECTS 

  • Chills, headache, dizziness, fever, vomiting, allergic reactions, nausea, arthralgia, low blood pressure and moderate low back pain 
  • Reversible haemolytic reactions; especially in those patients with blood groups A, B, and AB and (rarely) haemolytic anaemia requiring transfusion
  • Rarely a sudden fall in blood pressure and, in isolated cases, anaphylactic shock, even when the patient has shown no hypersensitivity to previous administration • (rarely) transient cutaneous reactions (including cutaneous lupus erythematosus – frequency unknown) 

STORAGE : 

(2° C – 8°C)

Potential complications can often be avoided by ensuring that patients:

  • are not sensitive to human immunoglobulin by initially injecting the product slowly (0.08 ml/kg/ body weight /hour), 
  • are carefully monitored for any symptoms throughout the infusion period. In particular, patients naive to human immunoglobulin, patients switched from an intravenous human immunoglobulin (IVIg) product or when there has been a long interval since the previous infusion, should be monitored at the hospital during the first infusion and for the first hour after the first infusion, in order to detect potential adverse signs. 

All other patients should be observed for at least 20 minutes after administration. In all patients, IVIg administration requires:

  • adequate hydration prior to the initiation of the infusion of IVIg, 
  • monitoring of urine output,
  • monitoring of serum creatinine levels, 
  • avoidance of concomitant use of loop diuretics

 

 

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FAQ

  • What is Megalotect Human Cytomegalovirus Immunoglobulin (CMVIG)?
  • Who can benefit from Megalotect CMVIG treatment?
  • How is Megalotect CMVIG administered?
  • Are there any side effects associated with Megalotect CMVIG treatment?
  • How effective is Megalotect CMVIG in preventing CMV infection?
  • Are there any contraindications for Megalotect CMVIG treatment?
  • What is the cost of Megalotect (Human CMV Immunoglobulin – CMVIG) in India?
  • How to buy Megalotect (Human CMV Immunoglobulin – CMVIG) online in India?
  • What are the key criteria for selecting a supplier?
What is Megalotect Human Cytomegalovirus Immunoglobulin (CMVIG)?

Megalotect CMVIG is a concentrated immunoglobulin product derived from human plasma, specifically designed to provide passive immunity against Cytomegalovirus infection. It contains high levels of antibodies against CMV, which can help protect patients at high risk of developing CMV disease.

Who can benefit from Megalotect CMVIG treatment?

Patients who may benefit from Megalotect CMVIG treatment include solid organ transplant recipients, hematopoietic stem cell transplant recipients, and patients with compromised immune systems due to cancer, HIV/AIDS, or other medical conditions.

How is Megalotect CMVIG administered?

Megalotect CMVIG is administered intravenously, typically as a single dose given shortly before or after transplantation or during the early stages of immunosuppressive therapy. The dosage and administration schedule should be determined by a healthcare professional based on the patient’s specific needs and risk factors.

Are there any side effects associated with Megalotect CMVIG treatment?

Like any medication, Megalotect CMVIG may cause side effects in some patients. Common side effects include headache, fever, chills, nausea, and vomiting. Rare but serious side effects include severe allergic reactions, kidney problems, and blood clots. Patients should report any side effects to their healthcare provider.

How effective is Megalotect CMVIG in preventing CMV infection?

Clinical studies have shown that Megalotect CMVIG can significantly reduce the incidence of CMV infection and disease in high-risk patients, particularly in solid organ transplant recipients. However, it is not a cure for CMV infection, and patients may still develop CMV disease despite prophylactic treatment.

Are there any contraindications for Megalotect CMVIG treatment?

Megalotect CMVIG should not be used in patients with a history of severe allergic reactions to immunoglobulin products or any of the components of Megalotect CMVIG. Patients with a history of IgA deficiency and selective IgA deficiency should also avoid Megalotect CMVIG due to the risk of anaphylactic reactions

What is the cost of Megalotect (Human CMV Immunoglobulin – CMVIG) in India?

The cost of Megalotect (Human CMV Immunoglobulin – CMVIG) in India varies as it is not widely approved locally and must often be imported. Factors like supplier availability, import charges, and currency fluctuations affect final price. For the latest cost details, contact 24/7QualityMeds at +91 9967979080.

How to buy Megalotect (Human CMV Immunoglobulin – CMVIG) online in India?

To buy Megalotect (Human CMV Immunoglobulin – CMVIG) online in India at a genuine price, contact 24/7QualityMeds. We assist with prescription verification, legal import procedures, sourcing from certified suppliers, and ensuring safe delivery.

What are the key criteria for selecting a supplier?

While selecting a supplier, we essentially ensure that the supplier holds a valid Good Distribution Practice (GDP) certificate and possesses a valid operating license. These credentials confirm that the suppliers adherence to International standards for the proper distribution of medicinal product

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