Velaglucerase alfa is indicated for long-term enzyme replacement therapy (ERT) for patients with type 1 Gaucher disease. Gaucher disease is an autosomal recessive disorder where GBA gene mutation results in deficiency of beta-glucocerebrosidase. This lysosomal enzyme catalyzes conversion of the sphingolipid glucocerebroside into glucose and ceramide. However, in deficiency of this enzyme glucocerebroside can accumulate in the lysosomal compartment of macrophages, giving rise to foam cells or “Gaucher cells”. Velaglucerase alfa catalyzes hydrolysis of this glucocerebroside, reducing its amount.
In clinical trials, this product reduced spleen and liver size, and improved anemia and thrombocytopenia.
The most common adverse reactions include hypersensitivity reactions, headache, dizziness, abdominal pain, nausea, back pain, joint pain, prolonged activated PTT, fatigue/asthenia, and pyrexia. Available data does not establish or exclude the absence of a velaglucerase alfa associated risk during pregnancy or any major birth defects, miscarriage, or any other adverse maternal or fetal outcomes. Sufficient data is not available to determine any effects on the breastfed infant or on milk production. Endogenous beta-glucocerebrosidase is present in human milk. The benefits of breastfeeding should be taken into consideration along with the mother’s clinical need for the medicine and any potential adverse effects on the breastfed child or from the underlying maternal condition.
Safety and effectiveness have been established for enzyme replacement therapy (ERT) in patients in the range of 4-17 years of age with type 1 Gaucher disease. The safety and efficacy profiles were similar between pediatric and adult patients. However, the efficacy and safety of the product has not been established in pediatric patients younger than 4 years of age.
Reported clinical experience has not identified differences in responses between geriatric and younger patients. Dose selection for an elderly patient should be approached cautiously, considering potential comorbid conditions.
Pricing and availability
Velaglucerase alfa is not currently registered in India and is therefore not available through regular pharmacies or standard distribution channels.
As this is a prescription-only medication, a price quotation for obtaining information on price of velaglucerase alfa in India, is shared only after reviewing valid medical documents and a doctor’s prescription. For the most up-to-date pricing and supply details, patients may contact our support team to access and buy velaglucerase alfa in India.
The price of velaglucerase alfa in India may differ based on factors such as market demand, supplier access, import regulations, and availability from international manufacturers. The total cost may also depend on shipping charges, origin country, documentation fees, and currency exchange rates.
Pricing may be affected by local taxes (GST) and any revisions in company or distributor pricing policies.
We assist patients in India with the safe and lawful access to velaglucerase alfa through the Named Patient Supply (NPS) program, ensuring compliance with all import regulations. Our services include document verification, import coordination, and doorstep delivery of the medicine.
Patient Access
Since velaglucerase alfa is not approved for commercial sale in India, it can be obtained only through the Named Patient Import Program (NPIP).
We help patients obtain unregistered medicines like velaglucerase alfa under the NPS route, maintaining full adherence to applicable legal and regulatory standards.
Velaglucerase alfa is available as 400 units/vial, for injection as a sterile, preservative free, white to off-white lyophilized powder requiring reconstitution and dilution before using. It is supplied in individually packaged single-dose glass vials.
Import Procedure
- Medicine Request Submission: Patients or caregivers can initiate the process by submitting a request along with the doctor’s prescription and treatment information.
- Filing Form 12A: A completed Form 12A, together with a valid prescription from a Registered Medical Practitioner (RMP), must be provided.
- Verification Process: All submitted documents are thoroughly reviewed to confirm the patient’s eligibility to import the medicine for personal medical use.
- Regulatory Approval: Once approval is granted by the Drugs Controller General (India), the import procedure is carried out in line with the approved prescription.
- Medicine Procurement: Our procurement specialists coordinate with licensed international suppliers to source the medicine at the best available rate while ensuring authenticity and quality.
- Product Delivery: After approval and shipment, logistics are managed to ensure safe, timely, and compliant delivery of the medicine to the patient’s address in India.
Documents required
To import velaglucerase alfa in India, patients must provide the following:
- A valid prescription indicating the medicine name, dosage, duration, and diagnosis.
- Recent medical history and diagnostic reports (preferably from the last three months).
- Government-issued ID proof and proof of residence.
- Import permit (if required).
Orders are confirmed only after the submission and verification of all necessary documents. Once the import authorization is granted, shipment velaglucerase alfa is arranged by a licensed global supplier—typically from the USA, Canada, Europe, or Australia.
This process ensures that patients in India can legally and securely access velaglucerase alfa. We coordinate with reliable international sources, maintain pricing transparency, and ensure all deliveries are pharmacist-verified and fully compliant with import regulations.
Looking for detailed product information or pricing? Our team at 24/7QualityMeds.com is here to help you anytime.










