Kineret is a prescription medication used to treat medical conditions like Rheumatoid Arthritis (RA) in adults, Neonatal-Onset Multisystem Inflammatory Disease (NOMID) in newborns, and in cases of decreased Interleukin-1 Receptor Antagonist (Blocks interleukin-1 from activating inflammation in the body).
How does Kineret (Anakinra) work?
Anakinra is the key component in the Kineret, which works as an immunosuppressive agent (that suppresses the immune system in the body). This replicates the interleukin 1 (IL-1) receptor antagonist in humans, which stops the receptors for signal molecules in the body known as interleukin 1. When the signal molecules are produced in higher quantities, it leads to inflammation of joints. By uniting the receptors that IL-1 usually attaches itself to, Anakinra obstructs IL-1 activity, resulting in relieving the symptoms of RA.Indications
Kineret is indicated in: 1) Rheumatoid Arthritis: Reduction in signs and symptoms and slowing the progression of the structural damage in moderately to severely active Rheumatoid arthritis (RA), in patients 18 years of age or older who have failed 1 or more disease-modifying antirheumatic drugs (DMARDs). 2) Cryopyrin-Associated Periodic Syndromes (episodes of uncontrolled inflammation) Treatment of Neonatal-onset Multisystem Inflammatory Disease (NOMID) 3) Deficiency of Interleukin-1 Receptor Antagonist (Blocks interleukin-1 from activating inflammation in the body)Side-effects
Rheumatoid Arthritis (RA) The common side effects are injection site reaction, worsening of Rheumatoid Arthritis, upper respiratory tract infection, headache, nausea, diarrhea, sinusitis, arthralgia (Joint pain), flu-like symptoms, and abdominal pain. NOMID: During the initial 6 months of treatment, injection site reactions, headache, vomiting, arthralgia, pyrexia (high body temperature), and nasopharyngitis are common side effects. DIRA: Upper respiratory tract infections, rash, pyrexia (high body temperature), influenza-like illness, and gastroenteritis are common side effects in patients with DIRA.Dosage and administration
Rheumatoid Arthritis (RA)- The recommended dose of Kineret for patients suffering from RA is 100mg per day, which is to be administered by subcutaneous injection every day. This dosage is maintained around the same time daily.
- Physicians should consider a dose of 100mg of Kineret administrated everyday for RA patients who have severe renal insufficiency or end-stage renal disease (defined as a creatinine clearance less than 30mL/min, as estimated from serum creatinine levels).
- The recommended starting dose of Kineret is 1-2mg/kg everyday for patients suffering from NOMID.
- Physicians should consider a dose of 1-2mg/kg of Kineret every other day for NOMID patients who have severe renal insufficiency or end stage renal disease (defined as a creatinine clearance less than 30mL/min, as estimated from serum creatinine levels).
- The recommended initial dose is 1-2mg/kg daily for patients with DIRA. The dose can be individually adjusted to a maximum of 8mg/kg daily to control active inflammation.
- Physicians should consider administration of the Kineret dose every other day for patients with DIRA who have several renal insufficiencies or end-stage renal disease(defined as a creatinine clearance less than 30mL/min, as estimated from serum creatinine levels).
