Foscavir is used for the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for the management of acyclovir-resistant mucocutaneous HSV infections in immunocompromised individuals.
Foscarnet sodium
Generic Name/API:Foscarnet sodium
Packaging:Single use vial
Storage:Stored at 20° and 25°C.
Dosage:For dosage information, please check the General Information section.
Strength:Foscavir contains 24 mg/mL (80 µmol/mL) foscarnet sodium.
Indication:Foscavir, a potent antiviral medication primarily used in immunocompromised individuals. It is prescribed for the treatment of cytomegalovirus (CMV) retinitis and mucocutaneous herpes simplex virus (HSV) infections that are resistant to acyclovir.
CMV RETINITIS
FOSCAVIR is approved for the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with acquired immunodeficiency syndrome (AIDS). FOSCAVIR combined with ganciclovir is indicated for patients who have relapsed after receiving monotherapy with either drug. CMV retinitis is a severe viral infection that affects the retina, the light-sensitive layer at the back of the eye. If not treated, it can cause progressive vision impairment and may eventually result in blindness.
Strength:
Foscavir is available as 24mg/ml single use vial.
Dosage:
The recommended dosage of Foscavir for the patients with normal renal function is
Dosage regimen for CMV retinitis patients:
| DOSAGE | INDUCTION |
| 90mg/kg | 1 to 2 hours infusion every 12 hours |
| 60mg/kg | Minimum 1 hour infusion every 8 hours |
The duration of the treatment cycle is 2 to 3 weeks, until healed.
Dosage regimen for acyclovir resistant HSV patients:
| DOSAGE | INDUCTION |
| 40mg/kg | Minimum 1 hour infusion every 8 to 12 hours |
The duration of treatment cycle is 2 to 3 weeks, until healed.
Dosage regimen for maintenance therapy:
| DOSAGE | INDUCTION |
| 90 To 12o mg/kg | 2 hour infusion, once a day |
Adverse reactions:
- Renal impairment
- Marrow Suppression
- Anemia
- Seizures
Storage:
- Store between 20° and 25°C. Protect from excessive heat (above 40°C) and from freezing.
RENAL IMPAIRMENT: Renal impairment often emerges during the second week of induction therapy but can occur at any stage of FOSCAVIR treatment. Regular monitoring of kidney function is essential during both induction and maintenance therapy (refer to the PATIENT MONITORING section). In many cases, increases in serum creatinine levels subside after discontinuing FOSCAVIR or modifying the dose, though reversal is not always assured.
MINERAL AND ELECTROLYTE ABNORMALITIES: FOSCAVIR has been associated with changes in serum electrolyte levels, such as hypocalcemia, hypophosphatemia, hyperphosphatemia, hypomagnesemia, and hypokalemia. FOSCAVIR may also cause a dose-dependent reduction in ionized serum calcium, which may not be apparent in total serum calcium levels. This effect is likely due to the chelation of divalent metal ions, such as calcium, by foscarnet.
SEIZURES: Seizures linked to mineral and electrolyte imbalances have been reported during FOSCAVIR treatment. Some seizure cases resulted in death. Risk factors for seizures include pre-existing renal impairment, low total serum calcium levels, and underlying central nervous system (CNS) conditions.
PRECAUTION: It is important to administer FOSCAVIR solutions only into veins with sufficient blood flow to ensure rapid dilution and distribution, minimizing the risk of local irritation. Local irritation and ulceration of the penile epithelium have been reported in male patients, possibly due to the presence of the drug in the urine. Both male and female patients have experienced genital irritation and ulceration during FOSCAVIR treatment. Maintaining adequate hydration and paying close attention to personal hygiene may help reduce the likelihood of these events.
Contraindication:
FOSCAVIR is contraindicated in patients with significant hypersensitivity to foscarnet sodium.
FAQ
How is FOSCAVIR administered?
Foscavir is administered intravenously IV. The dosage and duration depend on the specific condition being treated and the patient’s response to therapy. Dosage adjustments may be necessary for patients with renal impairment.
How does FOSCAVIR work?
Foscavir works by inhibiting viral DNA replication, targeting viruses like cytomegalovirus (CMV) and herpes simplex virus (HSV), including strains that are resistant to standard treatments like acyclovir.
What are the adverse reactions of FOSCAVIR?
The most severe adverse reactions are
- Renal impairment
- Seizures
- Anemia
- Marrow suppression
- Electrolyte Imbalance
How should FOSCAVIR be stored?
Store Foscavir at 20° and 25°C. Protect from light. Do not freeze.
What are the key criteria for selecting a supplier?
While selecting a supplier, we essentially ensure that the supplier holds a valid Good Distribution Practice (GDP) certificate and posssess a valid operating license. These credentials confirm that the suppliers adherence to International standards for the proper distribution of medicinal product.
What is the cost of Foscavir Injection in India?
The cost of Foscavir Injection in India varies as it must be imported. Pricing depends on factors such as international currency exchange rates (USD/EUR), import duties, and supplier availability. For the latest cost and order details, please contact 24/7 QualityMeds.
How to buy foscavir (foscarnet sodium) Injection in India?
To buy foscavir (foscarnet sodium) Injection in India at a genuine cost, contact 24/7 QualityMeds. We assist you in importing this medication legally and at the best possible price.
