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Zolbetuximab

Generic Name/API:Zolbetuximab
Packaging:100mg Vyloy is supplied as lyophilized powder in single dose vial.
Storage:Store refrigerated at 2ºC to 8ºC (36ºF to 46ºF)
Dosage:For dosage information, please check the General Information section.
Strength:100mg Zolbetuximab per vial
Indication:Vyloy is a monoclonal antibody used in combination with chemotherapy to treat advanced gastric and gastroesophageal junction (GEJ) adenocarcinoma. It specifically targets tumors that are HER2-negative and express the CLDN18.2 protein. Vyloy is the first FDA-approved therapy directed at this biomarker, offering a personalized treatment option.

Vyloy (Zolbetuximab) is indicated for the first-line treatment of adults with locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma that is human epidermal growth factor receptor 2 (HER2)-negative and expresses claudin 18.2 (CLDN18.2), as confirmed by an FDA-approved diagnostic test. It is used in combination with fluoropyrimidine- and platinum-based chemotherapy. This targeted therapy is specifically designed for tumors with CLDN18.2 positivity, a biomarker found in a subset of gastric and GEJ cancers, providing a more personalized treatment approach for eligible patients.

Strength:

Vyloy for injection is available as 100mg of zolbetuximab in lyophilized powder form, provided in single dose vial.

Dosage: Vyloy is administered in combination with fluoropyrimidine- and platinum-containing chemotherapy as follows: 

  • First dose: 800 mg/m2 IV
  • Subsequent doses are: 
    • 600 mg/m2 IV every 3 weeks, or 
    • 400 mg/m2 IV every 2 weeks
  • Treatment is to be continued till disease progression or any unacceptable toxicity is seen. 

Side-effects: 

  • Allergic Reactions including anaphylaxis and infusion related reactions 
  • Severe nausea and vomiting
  • Tingling or numbness of the arms or legs
  • Fatigue 
  • Decreased appetite

Storage:

  • Store Vyloy vials refrigerated at 2ºC to 8ºC (36ºF to 46ºF). 
  • Do not Freeze
  • Vyloy poses a risk of hypersensitivity reactions, including severe anaphylaxis and potentially fatal infusion-related reactions (IRRs), necessitating careful monitoring during administration. 
  • Vyloy is also classified as an emetogenic agent, with nausea and vomiting most frequently observed during the initial treatment cycle. To mitigate these effects, patients should receive antiemetic premedication prior to each infusion and be managed with additional antiemetics or fluid therapy as required. 
  • Depending on the severity of adverse reactions, infusion may need to be interrupted or VYLOY permanently discontinued.

 

 

Process to Import Medicine

FAQ

  • What is Vyloy?
  • How is Vyloy administered?
  • Can VYLOY be given to all gastric cancer patients?
  • Can VYLOY be given to all gastric cancer patients?
  • Can VYLOY be used alone?
  • What are the key criteria for selecting a supplier?
  • What documents are required for importing medicines?
  • How do we import shipments?
What is Vyloy?

Vyloy is a prescription monoclonal antibody.  It is the first FDA-approved targeted therapy designed to treat advanced gastric (stomach) or gastroesophageal junction (GEJ) adenocarcinoma in adults. Vyloy is used in combination with chemotherapy agents containing fluoropyrimidine and platinum.

How is Vyloy administered?

Vyloy is given as an intravenous (IV) infusion by a healthcare professional, in combination with other chemotherapy agents.

Can VYLOY be given to all gastric cancer patients?

No. Vyloy is only indicated for patients whose tumors test positive for claudin 18.2 (CLDN18.2) and are HER2-negative. An FDA-approved test must confirm eligibility

Can VYLOY be given to all gastric cancer patients?

The infusion should be immediately interrupted, and supportive care provided. Depending on the severity, VYLOY may need to be permanently discontinued.

 

Can VYLOY be used alone?

No. Vyloy is not used as a monotherapy; it must be administered in combination with fluoropyrimidine- and platinum-containing chemotherapy.

What are the key criteria for selecting a supplier?

While selecting a supplier, we essentially ensure that the supplier holds a valid Good Distribution Practice (GDP) certification and possesses a valid operating license. These credentials confirm the supplier’s adherence to international standards for the proper distribution of medicinal products.

What documents are required for importing medicines?

To import medicines, the following documents are required:

  1. Valid Prescription, which must include:
  • Date of prescription
  • Full name of the patient
  • Diagnosis
  • Name of the medicine
  • Dosage and required quantity
  • Signature and stamp of the prescribing doctor
  • Registration number of the doctor
  1. Patient Identification Proofs
  • In case the patient is a minor, identification proofs of the parents must also be submitted.
  • For foreign national patients, identification proofs of an Indian coordinator are mandatory.
How do we import shipments?

Shipments are ensured to be delivered in a validated coldchain box

  • What is blincyto?
  • What is blincyto used for?
  • What are the common side effects of blinatumomab use?
  • What is the cost of vyloy (zolbetuximab) injection in India?
  • How to buy vyloy (zolbetuximab) injection online in India?
What is blincyto?

  Blinatumomab belongs to the group of chemotherapeutic drugs “BiTES” or bispecific T-cell engagers.  Blinatumomab particularly is directed to CD19 on B cells and  CD3 on T-cells.

What is blincyto used for?

Blinatumomab or BLINCYTO is mainly used for  treatment of CD19-positive B-cell precursor acute lymphoblastic leukemia (ALL), relapsed or refractory CD19-positive B-cell precursor acute lymphoblastic leukemia (ALL), and CD19-positive Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia (ALL).

What are the common side effects of blinatumomab use?

Cytokine release syndrome, neurological toxicities, including ICANS (immune effector cell-associated neurotoxicity syndrome), infections, tumor lysis syndrome, neutropenia and febrile neutropenia, effects on ability to drive and use machines, elevated liver enzymes, pancreatitis, leukoencephalopathy

What is the cost of vyloy (zolbetuximab) injection in India?

The cost of vyloy (zolbetuximab-clzb) injection in India varies since it is not yet locally approved and must be imported. Supplier availability, import charges, and international currency fluctuations affect the final price. For the latest cost details, contact 24/7QualityMeds at +91 9967979080.

How to buy vyloy (zolbetuximab) injection online in India?

To buy vyloy (zolbetuximab) injection in India at a genuine price, contact 24/7QualityMeds. We assist with prescription verification, legal import procedures, sourcing from certified suppliers, and ensuring safe delivery to your location.

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"I’ve been using this medicine delivery service for a few months now, and I couldn’t be happier. The ordering process is simple and user-friendly, and the delivery is always prompt and reliable. I especially appreciate the timely updates, which help me stay on track with my prescriptions. The coordinator team is responsive and genuinely helpful, always ready to answer questions or resolve any issues. The packaging is secure, and the medicines always arrive in perfect condition. This service has made managing my health so much easier and stress-free. Highly recommended for anyone looking for convenience, reliability, and great customer care! "

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- Mr. Mohit Vishwakarma

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