Blincyto is a targeted immunotherapy approved worldwide to treat certain B-cell Acute Lymphoblastic Leukemia (ALL). The incidence of this disease is approximately 1-2 out of 1,00,000 persons. The adult patients suffering from ALL range from 7.3% to 57.8% whereas ALL in children accounts for 19% of childhood cancers in India by 2021. Patients looking for complete procurement guidance can also read our detailed guide on How to Buy Blinatumomab (Blincyto) in India Safely.
Mechanism of action
Blincyto works by the concept of BiTE (Bispecific T-Cell Engager) therapy, in which CD19 surface antigens on B cells are targeted. This enables tracking and attacking the malignant cells by engaging T cells (a type of white blood cell that functions in destroying the cells considered enemies). When the T cells are brought in proximity to the cancer cells, these T cells release toxins and induce cancer cell death (apoptosis). Currently, the BiTE therapy is being investigated for its usage in different types of cancers to benefit patients on a larger scale.Indications
Blincyto is indicated in the treatment of adults and children aged one month and older with:- CD19-positive B-cell precursor (immature B cell in bone marrow that shows the CD19 marker on its surface) Acute Lymphoblastic Leukaemia (ALL) in first or second complete recovery, along with Minimal Residual Disease (MRD), either greater than or equal to 0.1%.
- CD19-positive B-cell precursor Acute Lymphoblastic Leukaemia (ALL) recurrence or refractory type.
- CD19-positive B-cell Philadelphia chromosome-negative B-cell precursor Acute Lymphoblastic Leukaemia (ALL) in the consolidation phase of multiphase chemotherapy.
Side-effects
The most common side effects in patients taking Blincyto are high temperature, infusion-related reactions, headache, infection, musculoskeletal pain, low neutrophil count, low Red Blood Cell count, low thrombocyte count, and diarrhoea.Warnings and precautions
- Monitor the patients for infections
- Monitor if the patient shows the symptoms of Pancreatitis
- Follow the instructions as given by the manufacturer for preparation (including admixing) and administration
- Avoid operating heavy or potentially dangerous machinery
- Make sure to use preservative-free saline for children weighing less than 22 kg.
