Buy Sacituzumab Tirumotecan in India

Sacituzumab Tirumotecan

Generic Name/API:Sacituzumab Tirumotecan
Packaging:1 box of Sacituzumab Tirumotecan contains 1 vial.
Storage:Store at 2°C to 8°C
Dosage:For dosage information, please visit the General Information section.
Strength:200 mg lyophilized powder in a single-use vial for intravenous infusion
Indication:Sacituzumab Tirumotecan is indicated for adult patients with unresectable locally advanced or metastatic triple negative breast cancer (TNBC) who have received at least two prior systemic therapies (at least one of them for advanced or metastatic setting). sac-TMT monotherapy for the treatment of patients with locally advanced or metastatic EGFR-mutant non-small cell lung cancer (NSCLC) following progression on EGFR-TKI therapy only, or both EGFR-TKI and platinum-based chemotherapy, respectively.

Sacituzumab Tirumotecan (sac-TMT, also known as SKB264 or MK-2870) is a next-generation Trop-2-directed antibody-drug conjugate (ADC). It targets Trop-2, a protein overexpressed in multiple epithelial cancers, including breast cancer, lung cancer, and gynecologic malignancies. Early clinical studies suggest encouraging anti-tumor activity with a manageable safety profile, making sac-TMT an important emerging therapy in precision oncology.

It consists of:

  • A humanized monoclonal antibody targeting Trop-2
  • A cleavable linker
  • A belotecan-derived topoisomerase I inhibitor payload

STRENGTH: 

  • Lyophilized powder (vial) for reconstitution and intravenous infusion (200mg vial)
  • Single-use glass vials — sterile, preservative-free

DOSAGE: 

Sacituzumab Tirumotecan is approved by China’s NMPA at a standard clinical strength/dosing regimen of 5 mg/kg administered intravenously every other week.

Intravenous Dosing

  • 5 mg/kg  of  should be administered once weekly

The recommended dosing schedule are as follows:

It is given on a specific schedule, commonly involving day 1 and day 15 of a 28-day cycle, as approved by regulatory authorities.

The approved dosage and administration details are specific to the NMPA registration, and it is crucial to consult the official prescribing information provided by the manufacturer for the safe management of the treatment .

STORAGE: 

  • Because it is a biological therapeutic, its efficacy and safety depend strictly on temperature control. It must be refrigerated at 2°C to 8°C (36°F to 46°F)
  • Should not be frozen

Two significant side effects carry boxed warnings due to their potential severity:

Severe neutropenia and Severe diarrhea.

Severe diarrhea is also a common concern, affecting about 64% of patients, with severe (Grade 3-4) cases occurring in approximately 11% of patients. This can lead to dehydration and kidney problems. Patients should be closely monitored for diarrhea, and if it occurs, infectious causes should be ruled out, followed by prompt initiation of  anti-diarrhea medication like loperamide.

Other serious effects include hypersensitivity and infusion-related reactions, which can be severe. Patients should communicate any side effects they experience with their healthcare team promptly. Managing these side effects often involves withholding or reducing the drug dose, along with supportive care such as fluid and electrolyte replacement or administration of granulocyte colony-stimulating factors (G-CSF) for neutropenia.

Import Sacituzumab Tirumotecan in India through Named Patient Program

FAQ

  • What is Sacituzumab Tirumotecan used for?
  • How is Sacituzumab Tirumotecan administered?
  • What are the common side effects of Sacituzumab Tirumotecan?
  • What is Sacituzumab Tirumotecan used for?
  • Is Sacituzumab Tirumotecan a long-term treatment?
  • How is Sacituzumab Tirumotecan different from traditional chemotherapy?
  • Is Sacituzumab Tirumotecan approved for clinical use?
  • What is the cost of Sacituzumab Tirumotecan?
  • How to buy Sacituzumab Tirumotecan online in India?
What is Sacituzumab Tirumotecan used for?
  • Sacituzumab Tirumotecan is indicated for adult patients with unresectable locally advanced or metastatic triple negative breast cancer (TNBC) who have received at least two prior systemic therapies (at least one of them for advanced or metastatic setting).
  • sac-TMT monotherapy for the treatment of patients with locally advanced or metastatic EGFR-mutant non-small cell lung cancer (NSCLC) following progression on EGFR-TKI therapy only, or both EGFR-TKI and platinum-based chemotherapy, respectively.  
How is Sacituzumab Tirumotecan administered?

Sacituzumab Tirumotecan is administered through intravenous infusion.

What are the common side effects of Sacituzumab Tirumotecan?

The common side effects of Sacituzumab Tirumotecan include:

  • Neutropenia
  • Leukopenia 
  • Anemia 
  • Nausea — most frequent GI symptom (Grade 1/2 in majority)
  • Alopecia (hair loss) 
  • Fatigue and weakness
  • Diarrhea and vomiting
  • Stomatitis (oral mucositis)
  • Febrile neutropenia
What is Sacituzumab Tirumotecan used for?
  • Sacituzumab Tirumotecan is indicated for adult patients with unresectable locally advanced or metastatic triple negative breast cancer (TNBC) who have received at least two prior systemic therapies (at least one of them for advanced or metastatic setting).
  • sac-TMT monotherapy for the treatment of patients with locally advanced or metastatic EGFR-mutant non-small cell lung cancer (NSCLC) following progression on EGFR-TKI therapy only, or both EGFR-TKI and platinum-based chemotherapy, respectively.  
Is Sacituzumab Tirumotecan a long-term treatment?

Sacituzumab Tirumotecan is typically administered until disease progression, unacceptable toxicity occurs or until the patient/doctor decides to stop treatment. The duration of treatment depends on factors such as tumor response, patient tolerance, side effect management and overall clinical condition. Some patients may remain on therapy for several months if clinical benefit is observed.

How is Sacituzumab Tirumotecan different from traditional chemotherapy?

Unlike conventional chemotherapy, Sacituzumab Tirumotecan is a targeted therapy that aims to deliver chemotherapy directly to cancer cells using antibody-drug conjugate technology.

Is Sacituzumab Tirumotecan approved for clinical use?

The regulatory status varies globally. In many regions, the therapy is still undergoing clinical evaluation and may be available through clinical trials.

What is the cost of Sacituzumab Tirumotecan?

The cost of Sacituzumab Tirumotecan in India varies depending on factors such as dosage strength, treatment requirements, availability and import procedures. Since pricing may change based on supplier and procurement channels, patients should contact 24/7QualityMeds for the latest Sacituzumab Tirumotecan price in India, availability and access information.

How to buy Sacituzumab Tirumotecan online in India?

To buy Sacituzumab Tirumotecan online in India, patients typically need a valid prescription from a licensed healthcare provider. Once prescribed, 24/7QualityMeds can assist with medicine availability, procurement and import support where applicable. To learn how to buy Sacituzumab Tirumotecan in India, contact 24/7QualityMeds at +91 9967979080 for personalized assistance.

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