Kineret is a prescription medication used to treat medical conditions like Rheumatoid Arthritis (RA) in adults, Neonatal-Onset Multisystem Inflammatory Disease (NOMID) in newborns, and in cases of decreased Interleukin-1 Receptor Antagonist (Blocks interleukin-1 from activating inflammation in the body).

How does Kineret (Anakinra) work?

Anakinra is the key component in the Kineret, which works as an immunosuppressive agent (that suppresses the immune system in the body). This replicates the interleukin 1 (IL-1) receptor antagonist in humans, which stops the receptors for signal molecules in the body known as interleukin 1. When the signal molecules are produced in higher quantities, it leads to inflammation of joints. By uniting the receptors that IL-1 usually attaches itself to, Anakinra obstructs IL-1 activity, resulting in relieving the symptoms of RA.

Indications

Kineret is indicated in:

1)     Rheumatoid Arthritis: Reduction in signs and symptoms and slowing the progression of the structural damage in moderately to severely active Rheumatoid arthritis (RA), in patients 18 years of age or older who have failed 1 or more disease-modifying antirheumatic drugs (DMARDs).

2)     Cryopyrin-Associated Periodic Syndromes (episodes of uncontrolled inflammation) Treatment of Neonatal-onset Multisystem Inflammatory Disease (NOMID)

3)     Deficiency of Interleukin-1 Receptor Antagonist (Blocks interleukin-1 from activating inflammation in the body) 

Side-effects

Rheumatoid Arthritis (RA)

The common side effects are injection site reaction, worsening of Rheumatoid Arthritis, upper respiratory tract infection, headache, nausea, diarrhea, sinusitis, arthralgia (Joint pain), flu-like symptoms, and abdominal pain. 

NOMID: During the initial 6 months of treatment, injection site reactions, headache, vomiting, arthralgia, pyrexia (high body temperature), and nasopharyngitis are common side effects.

DIRA: Upper respiratory tract infections, rash, pyrexia (high body temperature), influenza-like illness, and gastroenteritis are common side effects in patients with DIRA.

Dosage and administration

Rheumatoid Arthritis (RA)

• The recommended dose of Kineret for patients suffering from RA is 100mg per day, which is to be administered by subcutaneous injection every day. This dosage is maintained around the same time daily.
• Physicians should consider a dose of 100mg of Kineret administrated everyday for RA patients who have severe renal insufficiency or end-stage renal disease (defined as a creatinine clearance less than 30mL/min, as estimated from serum creatinine levels).

NOMID

• The recommended starting dose of Kineret is 1-2mg/kg everyday for patients suffering from NOMID.
• Physicians should consider a dose of 1-2mg/kg of Kineret every other day for NOMID patients who have severe renal insufficiency or end stage renal disease (defined as a creatinine clearance less than 30mL/min, as estimated from serum creatinine levels).

DIRA

•  The recommended initial dose is 1-2mg/kg daily for patients with DIRA. The dose can be individually adjusted to a maximum of 8mg/kg daily to control active inflammation.
• Physicians should consider administration of the Kineret dose every other day for patients with DIRA who have several renal insufficiencies or end-stage renal disease(defined as a creatinine clearance less than 30mL/min, as estimated from serum creatinine levels).

Where to buy Kineret in India?

Since Kineret is not registered in India, it’s not possible to get access in India except through legal means. However, we are here to help you in this process to import anakinra in India safely and on time. The anakinra price in India is completely based on the parameters like its distribution status, supply chain management, transportation, and tariffs, but we can assure you that we offer it at a very competitive price. The packaging comes as a single-use prefilled syringe designed for subcutaneous injections. The dosage of the injection is 100mg/0.67mL solution. We will walk you through this systematic protocol to import anakinra.

1) Placing an order request

You can request by notifying us regarding Kineret on our website portal. Make sure to send the patient’s prescriptions with the past health record. 

2) Report submission of the Form

Complete the submission of Form No. 12A by attaching the patient’s prescription from a Registered Medical Practitioner (RMP).

3) Validation and cross-border importation

We check all the related documents and personal identification proofs to ensure the fulfillment of the eligibility criteria. And, when the permission from the Drugs Controller General (India) to import is obtained, our team makes the next move.

4) Vendor selection

Our professionals search for the global vendors and lock in your order at the best affordable value only after understanding their credibility.

5) Order fulfilment

All further processes, like transportation, transit, and doorstep delivery, are completely taken care of by our company staff.

Conclusion

Kineret availability often poses challenges; that’s where 24/7QualityMeds comes in. Our experienced team handles the complete process seamlessly. Get in touch with us, and we will handle the rest. Visit our website and explore more for updates.