Working hours24*7 AvailableCall us+91 9967979080
   
Taletrectinib

Taletrectinib

Generic Name/API:Taletrectinib
Packaging:Bottle of 30 capsules in a carton containing three bottles of 30 count for a total of 90 capsules per carton
Storage:Store at 20°C to 25°C
Dosage:For dosage information, please check the General Information section.
Strength:Capsules: 200 mg of taletrectinib
Indication:IBTROZI is a next-generation oral targeted therapy that represents a significant advancement in precision medicine for specific types of cancer. It functions as a highly selective tyrosine kinase inhibitor (TKI) specifically designed to target oncogenic ROS1 and NTRK gene fusions.

IBTROZI (Taletrectinib) is a kinase inhibitor indicated for the treatment of adult patients with locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC). Taletrectinib is now a preferred treatment for advanced ROS1-positive NSCLC, including brain metastases and resistance mutations, per updated NCCN guidelines. (JUNE 2025)

STRENGTH:

Capsules: 200 mg of taletrectinib

DOSAGE: 

600 mg orally once daily on an empty stomach (no food intake at least 2 hours before and 2 hours after taking IBTROZI)

Dose Reduction : 

Dosage Reduction Recommended Dosage
First dose Reduction 400mg OD
Second dose Reduction 200mg OD
Permanently discontinue  For patients not able to tolerate less then 200 mg

SIDE EFFECTS: 

  • Neurological: Dizziness, cognitive dysfunction, mood changes, peripheral neuropathy.
  • Visual: Blurred vision, double vision, visual impairment
  • Gastrointestinal: Nausea, vomiting, diarrhea, constipation, decreased appetite
  • Fatigue: Feeling tired or weak
  • Musculoskeletal: Muscle pain, joint pain
  • Skin: Rash, itching
  • Edema: Swelling, particularly in the ankles and feet
  • Anemia: Low red blood cell count
  • Elevated Liver Enzymes: As mentioned above, can be detected through blood tests.

ADVERSE REACTIONS :

  • Hepatotoxicity :

88% of patients treated with IBTROZI experienced increased aspartate aminotransferase (AST), including 10% Grade 3 or 4. Increased alanine aminotransferase (ALT) occurred in 85% of patients treated with IBTROZI, including 13% Grade 3 or 4. The median time to first onset of AST or ALT elevation was 15 days (range: 3 days to 20.8 months)

  •  Interstitial Lung Disease/Pneumonitis:

Interstitial lung disease (ILD)/pneumonitis occurred in 2.3% of patients treated with IBTROZI, including Grade 3 or 4 in 1.1% of patients. The median time to first onset of ILD/pneumonitis was 3.8 months (range: 12 days to 11.8 months)

  •  QTc Interval Prolongation :

351 patients who underwent at least one post baseline ECG assessment, 13% experienced an increase in QTcF of >60 msec compared to baseline after receiving IBTROZI and 2.6% had an increase in QTcF to >500 msec. Overall, 3.4% of patients had Grade ≥3 QTc interval prolongation. The median time from the first dose of IBTROZI to the onset of ECG QT prolongation was 22 days (range: 1 day to 38.7 months)

  •  Hyperuricemia 

14% of patients treated with IBTROZI experienced hyperuricemia reported as an adverse reaction, with 16% of these patients requiring urate-lowering medication without pre-existing gout or hyperuricemia. Hyperuricemia Grade ≥3 occurred in one patient. The median time to first onset of hyperuricemia was 2.1 months (range: 7 days to 35.8 months).

  • Myalgia with Creatine Phosphokinase Elevation

Myalgia occurred in 10% of patients treated with Ibtrozi. The median time to first onset of myalgia was 11 days (range: 2 days to 10 months)

  • Skeletal fractures 

3.4% of patients experienced fractures including 1.4% Grade 3. Some fractures occurred in the setting of an accidental fall or other predisposing factors such as osteoporosis, bone metastasis, and age-related degenerative conditions. Fractures involved the ribs (1.4%), spine (0.9%), femur (0.6%), humerus (0.3%), and acetabulum (0.3%). The median time to first onset of fracture was 10.7 months (range: 26 days to 29.1 months).

STORAGE : 

  • Store at 20°C to 25°C
  • Neurological Adverse Reactions: Ibtrozi can cause neurological side effects, including dizziness, cognitive dysfunction (difficulty thinking or concentrating), mood changes, and even seizures.
  • QTc Interval Prolongation: Ibtrozi can prolong the QTc interval, a measure of the heart’s electrical activity. This can increase the risk of a potentially dangerous heart rhythm abnormality called torsades de pointes.
  • Visual Impairment: Ibtrozi can cause visual issues such as blurred vision, double vision, and other visual disturbances. It’s important to report any changes in your vision to your doctor promptly as ophthalmic exams may be required.
  • Interstitial Lung Disease (ILD)/Pneumonitis: Although rare, Ibtrozi can cause ILD or pneumonitis, which are serious lung conditions. Symptoms may include shortness of breath, cough, and fever.
  • Elevated Hepatic Transaminases: Ibtrozi can cause an increase in liver enzymes (hepatic transaminases).. Dose adjustments or discontinuation may be necessary if liver enzyme levels become significantly elevated.
  • Embryo-Fetal Toxicity: Ibtrozi can harm a developing fetus. Women who are pregnant or could become pregnant should not take Ibtrozi. Effective contraception is crucial for both women and men with female partners of reproductive potential while taking Ibtrozi and for a period of time after the last dose.
  • Lactation: It’s not known whether Ibtrozi passes into breast milk. Because of the potential for serious adverse reactions in nursing infants, women should not breastfeed while taking Ibtrozi and for a period of time after the last dose.

Process to Import Medicine

FAQ

  • What is Ibtrozi (taletrectinib) used for?
  • **How does taletrectinib work to treat cancer?**
  • What are the common side effects of Ibtrozi?
  • How is Ibtrozi administered and what is the recommended dosage?
  • Are there any serious side effects or risks associated with taletrectinib?
  • Can I take Ibtrozi if I am pregnant or breastfeeding?
  • What is the cost of ibtrozi (taletrectinib) in India?
  • How to buy Ibtrozi (taletrectinib) online in India?
  • What are the key criteria for selecting a supplier?
What is Ibtrozi (taletrectinib) used for?

Ibtrozi is used to treat adults with ROS1-positive non-small cell lung cancer (NSCLC) that has spread or cannot be removed by surgery, especially if previous treatments have failed. 

**How does taletrectinib work to treat cancer?**

Taletrectinib is a targeted therapy that inhibits ROS1 and NTRK gene mutations, which drive the growth of certain cancers, thereby helping to control tumor progression. 

What are the common side effects of Ibtrozi?

Common side effects include fatigue, nausea, diarrhea, liver enzyme elevations, dizziness, and swelling. Serious side effects are rare but can include liver problems or neurological symptoms.

How is Ibtrozi administered and what is the recommended dosage?

Ibtrozi is taken orally, usually once daily. The exact dose depends on the patient’s condition and doctor’s instructions; always follow your healthcare provider’s guidance. 

Are there any serious side effects or risks associated with taletrectinib?

Yes, serious risks include liver toxicity, neurological issues, and allergic reactions. Regular monitoring by your healthcare provider is essential to manage these risks. 

Can I take Ibtrozi if I am pregnant or breastfeeding?

It is not recommended for use during pregnancy or breastfeeding due to potential risks to the baby. Discuss with your doctor for safer alternatives. 

What is the cost of ibtrozi (taletrectinib) in India?

The cost of ibtrozi (taletrectinib) in India varies since it is not yet locally approved and must be imported through legal channels. The final price depends on supplier availability, import duties, and international currency fluctuations. For the latest price and supply updates, contact 24/7QualityMeds at +91 9967979080.

How to buy Ibtrozi (taletrectinib) online in India?

To buy ibtrozi (taletrectinib) in India safely and at a genuine price, contact 24/7QualityMeds. We assist patients with legal import procedures, prescription verification, sourcing from trusted suppliers, and ensuring secure delivery across India.

What are the key criteria for selecting a supplier?

While selecting a supplier, we essentially ensure that the supplier holds a valid Good Distribution Practice (GDP) certificate and possesses a valid operating license. These credentials confirm that the suppliers adherence to International standards for the proper distribution of medicinal product

"I am very happy with experience of delivery medicine! From start to finish, everything was smooth, professional, and exceeded my expectations. The coordinator was incredibly responsive and friendly, and the product itself best in condition exactly as described. Delivery was fast, packaging was secure, and I felt truly valued as a customer. I’ll be coming back and recommending this to friends and family. Once again Thanks for delivering medicine with in 24 hours which help my wife to start treatment on time. "

- Mr. Sanjay More

"I’ve been using this medicine delivery service for a few months now, and I couldn’t be happier. The ordering process is simple and user-friendly, and the delivery is always prompt and reliable. I especially appreciate the timely updates, which help me stay on track with my prescriptions. The coordinator team is responsive and genuinely helpful, always ready to answer questions or resolve any issues. The packaging is secure, and the medicines always arrive in perfect condition. This service has made managing my health so much easier and stress-free. Highly recommended for anyone looking for convenience, reliability, and great customer care! "

- Mr. Nilesh Patankar

"I’m really impressed with the level of service. From placing the order to receiving the medicines, everything is smooth and hassle-free. The coordinator even called several times for updates my package. It’s rare to find such thoughtful service these days!"

- Mr. Mohit Vishwakarma

About us

We're a dedicated team of medicine access experts, doctors and pharmacists. We come from all over the world. And we've lost family and friends who could not get the medicine they needed because they lived in the wrong country.

Our mission is to get everyone the right treatment at the right time. Wherever you live. Because you should not suffer or die if a treatment that could help you exists somewhere.

Learn more ›

If you have any questions or need help, we're a phone call away. Our team is available from Monday to Friday between 9 a.m and 6 p.m CET

We usually respond to emails within 24 working hours

Call +919967979080
Email [email protected]

Worldwide Delivery

Afghanistan, Albania, Algeria, American Samoa, Angola, Anguilla, Antarctica, Antigua & Barbuda, Armenia, Aruba, Australia, Austria, Azerbaijan, Bahamas, Bahrain, Bangladesh, Barbados, Belarus, Belgium, Belize, Benin, Bermuda, Bhutan, Bolivia, Bosnia & Herzegovina, Botswana, Bouvet Island, Brazil, British Indian Ocean Territory, British Virgin Islands, Brunei, Bulgaria, Burkina Faso, Burundi, Cambodia, Cameroon, Canada, Cape Verde, Cayman Islands, Central African Republic, Chad, Chile, China, Christmas Island, Cocos (Keeling) Islands, Colombia, Comoros, Congo - Brazzaville, Congo - Kinshasa, Cook Islands, Costa Rica, Croatia, Cuba, Cyprus, Czechia, Côte d'Ivoire, Denmark, Djibouti, Dominica, Dominican Republic, Ecuador, Egypt, El Salvador, Equatorial Guinea, Eritrea, Estonia, Eswatini, Ethiopia, Falkland Islands, Faroe Islands, Fiji, Finland, France, French Guiana, French Polynesia, French Southern Territories, Gabon, Gambia, Georgia, Germany, Ghana, Gibraltar, Greece, Greenland, Grenada, Guadeloupe, Guam, Guatemala, Guernsey, Guinea, Guinea-Bissau, Guyana, Haiti, Heard & McDonald Islands, Honduras, Hong Kong SAR China, Hungary, Iceland, India, Indonesia, Iran, Iraq, Ireland, Isle of Man, Israel, Italy, Jamaica, Japan, Jersey, Jordan, Kazakhstan, Kenya, Kiribati, Kuwait, Kyrgyzstan, Laos, Latvia, Lebanon, Lesotho, Liberia, Libya, Liechtenstein, Lithuania, Luxembourg, Macao SAR China, Madagascar, Malawi, Malaysia, Maldives, Mali, Malta, Marshall Islands, Martinique, Mauritania, Mauritius, Mayotte, Mexico, Micronesia, Moldova, Monaco, Mongolia, Montenegro, Montserrat, Morocco, Mozambique, Myanmar (Burma), Namibia, Nauru, Nepal, Netherlands, New Caledonia, New Zealand, Nicaragua, Niger, Nigeria, Niue, Norfolk Island, North Korea, North Macedonia, Northern Mariana Islands, Norway, Oman, Pakistan, Palau, Palestinian Territories, Panama, Papua New Guinea, Paraguay, Peru, Philippines, Pitcairn Islands, Poland, Portugal, Qatar, Romania, Russia, Rwanda, Réunion, Saint Barthélemy, Samoa, San Marino, Saudi Arabia, Senegal, Serbia, Seychelles, Sierra Leone, Singapore, Slovakia, Slovenia, Solomon Islands, Somalia, South Africa, South Georgia & South Sandwich Islands, South Korea, Spain, Sri Lanka, St. Helena, St. Kitts & Nevis, St. Lucia, St. Martin, St. Pierre & Miquelon, St. Vincent & Grenadines, Sudan, Suriname, Svalbard & Jan Mayen, Sweden, Switzerland, Syria, São Tomé & Príncipe, Taiwan, Province of China, Tajikistan, Tanzania, Thailand, Timor-Leste, Togo, Tokelau, Tonga, Trinidad & Tobago, Tunisia, Turkey, Turkmenistan, Turks & Caicos Islands, Tuvalu, U.S. Outlying Islands, U.S. Virgin Islands, Uganda, Ukraine, United Arab Emirates, United Kingdom, United States, Uruguay, Uzbekistan, Vanuatu, Vatican City, Venezuela, Vietnam, Wallis & Futuna, Western Sahara, Yemen, Zambia, Zimbabwe, Åland Islands

Disclaimer

All trademarks, logos, brand names, and product names appearing on this website are the property of their respective owners. 247qualitymeds.com does not claim any ownership or affiliation with these trademarks or brands. They are used solely for informational and reference purposes to help users identify products and understand their intended use. The presence of any trademark or brand name on this website does not imply endorsement, sponsorship, or association with 247qualitymeds.com in any form.