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Ivacaftor

Ivacaftor

Generic Name/API:Ivacaftor
Packaging:Pack size of 28 sachets (contains 4 individual wallets with 7 sachets per wallet).
Storage:(20°C to 25°C)
Dosage:For dosage information, please check the General Information section.
Strength:5 different strengths (5.8-mg, 13.4-mg, 25-mg, 50-mg, and 75-mg packets)
Indication:Ivacaftor is a prescription medicine used to treat cystic fibrosis (CF) in patients with specific genetic mutations.It belongs to a class of medications called cystic fibrosis transmembrane conductance regulator (CFTR) potentiators.

KALYDECO (Ivacaftor) is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator indicated for the treatment of cystic fibrosis (CF) in patients age 1 month and older who have at least one mutation in the CFTR gene that is responsive to ivacaftor based on clinical and/or in vitro assay data.

STRENGTH :

5 different strengths (5.8-mg, 13.4-mg, 25-mg, 50-mg, and 75-mg packets)

DOSAGE:  

AGE WEIGHT DOSAGE ADMINISTRATION
1month > 2 months 3 kg or > One 5.8 mg packet every 12 hours   Mixed with one teaspoon (5 ml) of soft food or liquid and administered orally with fatcontaining food  
2 months >4 months 3kg or > One 13.4 mg packet every 12 hours Mixed with one teaspoon (5 ml) of soft food or liquid and administered orally with fatcontaining food  
4 months> 6 months 5kg or > One 25 mg packet every 12 hours Mixed with one teaspoon (5 ml) of soft food or liquid and administered orally with fatcontaining food  
6 months >6 years 5kg to > 7 kg

7kg to <14 kgs

14kg or <

One 25 mg packet every 12 hours 

One 50 mg packet every 12 hours

One 75 mg packet every 12 hours

Mixed with one teaspoon (5 ml) of soft food or liquid and administered orally with fatcontaining food  
<6 years One 150 mg tablet every 12 hours  Taken orally with fatcontaining food  

SIDE EFFECTS:

  • Severe Liver Problems: 
  • Elevated Liver Enzymes
  • Development or Worsening of Liver Fibrosis
  • Changes in Vision
  • Upper Respiratory Tract Infection
  • Stomach Pain
  • Diarrhea 
  • Rash 
  • Dizziness

STORAGE

(20°C to 25°C).

  • Liver Problems: Kalydeco can cause liver problems.Symptoms like jaundice (yellowing of the skin or eyes), dark urine, fatigue, or loss of appetite, can be seen 
  • Cataracts: Kalydeco is associated with the development of cataracts, especially in children. Baseline and follow-up eye examinations are recommended, particularly in younger patients.
  • Combination with Other Medications: Kalydeco can interact with many other medications, including certain antifungals, antibiotics, and immunosuppressants. Some medications may increase or decrease the concentration of Kalydeco in the blood, potentially leading to side effects or reduced effectiveness. 
  • Use with CYP3A Inhibitors/Inducers: Certain substances, like grapefruit juice and some medications, can inhibit or induce the CYP3A enzyme system, which is involved in the metabolism (breakdown) of Kalydeco. This can affect Kalydeco levels in the blood..
  • Pregnancy and Breastfeeding: There is limited data on the use of Kalydeco during pregnancy. 

Process to Import Medicine

FAQ

  • What is Kalydeco (ivacaftor)?
  • How does Kalydeco work?
  • Who can take Kalydeco?
  • What are the benefits of taking Kalydeco?
  • What are the common side effects of Kalydeco?
  • What is the cost of Ivacaftor (Kalydeco) in India?
  • How to buy Ivacaftor (Kalydeco) online in India?
What is Kalydeco (ivacaftor)?

Kalydeco (ivacaftor) is a prescription medication used to treat Cystic Fibrosis (CF) in people ages 4 months and older who have specific mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene. It helps improve the function of the faulty CFTR protein, which is responsible for regulating the flow of salt and water in and out of cells.

How does Kalydeco work?

The CFTR protein, when mutated, often gets trapped inside the cell. Kalydeco works by helping the CFTR protein channel open and stay open longer, allowing chloride to flow through and improving the balance of salt and water in the lungs and other organs. This, in turn, helps to thin mucus and ease CF symptoms.

Who can take Kalydeco?

Kalydeco is not a universal treatment for CF. It is only effective for individuals with specific mutations in the CFTR gene. Before starting Kalydeco, genetic testing is crucial to determine if you have one of the approved mutations. Your doctor can provide more information about whether Kalydeco is right for you.

What are the benefits of taking Kalydeco?

Studies have shown that Kalydeco can lead to significant improvements in people with eligible CF mutations, including:

  • Improved lung function
  • Reduced sweat chloride levels (a marker of CF)
  • Weight gain
  • Reduced pulmonary exacerbations (flare-ups of lung infections)
  • Improved quality of life

 

What are the common side effects of Kalydeco?

Like all medications, Kalydeco can cause side effects. Common side effects include:

  • Headache
  • Upper respiratory tract infection (common cold)
  • Stomach pain
  • Diarrhea
  • Dizziness
  • Rash

 

What is the cost of Ivacaftor (Kalydeco) in India?

The cost of Ivacaftor (Kalydeco) in India varies as it is not locally marketed and must be imported. Price depends on supplier availability, import charges, and exchange rates. For updated cost details, contact 24/7QualityMeds at +91 9967979080.

How to buy Ivacaftor (Kalydeco) online in India?

To buy Ivacaftor (Kalydeco) online in India, connect with 24/7QualityMeds. We support patients with valid prescription verification, legal import process, sourcing from trusted suppliers, and secure delivery at the best possible price.

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