Working hours24*7 AvailableCall us+91 9967979080
   
GLOFITAMAB

Glofitamab

Generic Name/API:Glofitamab
Packaging:One vial/pack
Storage:Store at 2°C to 8°C.
Dosage:For dosage information, please visit the General Information section.
Strength:Injection available in following strengths 2.5 mg/2.5 mL (1 mg/mL) in a single-dose vial 10 mg/10 mL (1 mg/mL) in a single-dose vial.
Indication:COLUMVI (glofitamab-gxbm) is indicated for the treatment of adult patients with relapsed  or refractory diffuse large B-cell lymphoma (DLBCL), not otherwise specified, including DLBCL arising  from indolent lymphoma, after two or more lines of systemic therapy. This indication is approved  under accelerated approval based on response rate. 

Columvi (glofitamab) is a novel bispecific antibody that targets CD20 on B cells and CD3 on T cells,  effectively directing the immune system to eliminate cancer cells. It has high efficacy in relapsed or  refractory diffuse large B-cell lymphoma (DLBCL), with strong overall and complete response rates.  Columvi offers a fixed-duration treatment regimen, providing clarity and convenience for both  physicians and patients. Approved by both the FDA and the European Commission under accelerated  pathways, it is a globally recognized option for difficult-to-treat lymphoma cases. Its step-up dosing  approach also ensures a manageable safety profile, particularly in reducing the risk of cytokine release  syndrome. 

Strength: Columvi is supplied in two strengths 2.5mg and 10mg.  

Dosage:

The recommended dosage regimen for Columvi is as follows: 

TREATMENT CYCLE  DAY  DOSE  DURATION OF  

INFUSION
Cycle 1  Day 1  Obinutuzumab
Day 8  Set-up  

dose 1

 2.5mg 4hours
Day 15  Set-up  

dose 2

 10mg
Cycle 2  Day 1  30mg  4 Hours
Cycle 3 to 12  Day 1  30mg  2 Hours

Storage: Store refrigerated at 2°C to 8°C, protect from light. Do not freeze. 

Adverse reaction:

The following are the adverse reactions seen with Columvi 

Cytokine release syndrome 

CRS is a condition where the body’s immune system overreacts to a trigger, leading to a rapid and  excessive release of inflammatory chemicals called cytokines. Signs of CRS includes fever, rapid  heartbeat, low blood pressure, chills, and reduced oxygen levels. In CT it was seen that CRS generally  began around 14 hours after infusion and lasted a median of 2 days, resolving in 98% of cases. The  highest incidence occurred after the initial 2.5 mg step-up dose, with decreasing frequency following  higher doses.  

Neurological disorders 

COLUMVI may cause serious and potentially fatal neurologic toxicity, including Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS). In clinical trials involving 145 patients, common  neurologic side effects included headache (10%), peripheral neuropathy (8%), dizziness or vertigo (7%),  and mental status changes (4.8%), such as confusion, disorientation, and delirium. The risk may be  increased when COLUMVI is used with other medications that cause dizziness or cognitive changes. 

Musculoskelatal pain: 

Musculoskeletal pain is a commonly reported adverse effect of COLUMVI in clinical trials. It can involve  discomfort in the muscles, joints, bones, or surrounding tissues and may manifest as general body  aches, joint stiffness, or localized pain. This type of pain is thought to be related to immune system  activation or cytokine release, both of which are known effects of COLUMVI and similar  immunotherapies. While the severity is usually mild to moderate, any persistent or worsening  musculoskeletal pain should be assessed by a healthcare provider. 

COLUMVI carries several serious risks, including cytokine release syndrome (CRS), neurologic toxicity,  infections, tumor flare, and embryo-fetal toxicity. CRS occurred in 70% of patients, with severe cases  in a small percentage; it typically starts within hours of dosing and can recur. Neurologic toxicities,  including serious events like ICANS, were reported in 4.8% of patients, with symptoms such as headaches, dizziness, and altered mental status. Serious or fatal infections, including COVID-19 and  sepsis, occurred in 16% of patients. Tumor flare, seen in 12% of patients, may lead to localized pain or  organ compression, especially in those with bulky tumors. Additionally, COLUMVI may harm a fetus;  therefore, effective contraception is required during treatment and for one month afterward. Close  monitoring and adherence to dosing protocols are essential to manage these risks. 

Process to Import Medicine

FAQ

  • What is COLUMVI used for?
  • How is COLUMVI administered?
  • What are the serious risks associated with COLUMVI?
  • Can COLUMVI be administered by pregnant or breastfeeding women?
  • What are the key criteria for selecting a supplier?
  • How do we import shipment?
  • What is the cost of Columvi (glofitamab) in India?
  • How to buy Columvi (glofitamab) in India?
What is COLUMVI used for?

COLUMVI is used to treat adults with relapsed or refractory diffuse large B-cell lymphoma  (DLBCL) after at least two prior lines of treatment. 

How is COLUMVI administered?

 COLUMVI is given as an intravenous (IV) infusion following a step-up dosing schedule to reduce the  risk of cytokine release syndrome (CRS). Treatment is usually done in a hospital or clinic.

What are the serious risks associated with COLUMVI?

COLUMVI can cause: 

  • Cytokine release syndrome (CRS) 
  • Neurologic toxicity  
  • Serious infections
  • Tumor flare 
Can COLUMVI be administered by pregnant or breastfeeding women?

No. COLUMVI may harm your unborn baby. Avoid pregnancy during treatment and for at least one  month after the last dose. It is also not recommended during breastfeeding.

What are the key criteria for selecting a supplier?

While selecting a supplier, we essentially ensure that the supplier holds a valid Good Distribution  Practice (GDP) certificate and posssess a valid operating license. These credentials confirm that  the suppliers adherence to International standards for the proper distribution of medicinal  product. 

How do we import shipment?

Shipments are delivered in a validated cold chain box to ensure the medication remains safe and maintains its required temperature throughout transit.

What is the cost of Columvi (glofitamab) in India?

Cost of  Columvi (glofitamab) may vary each time, as the medicine is not approved in India and must be imported. Factors such as international currency exchange rates (USD/EUR) and import duties can affect the final cost. For more details, please contact 247 QualityMeds.

How to buy Columvi (glofitamab) in India?

To buy Columvi (Glofitamab) in India at a genuine and affordable price, contact 247 Quality Meds. We help you import Columvi legally with full documentation, ensuring timely delivery and cost efficiency. Call now: 9967979080.

"I am very happy with experience of delivery medicine! From start to finish, everything was smooth, professional, and exceeded my expectations. The coordinator was incredibly responsive and friendly, and the product itself best in condition exactly as described. Delivery was fast, packaging was secure, and I felt truly valued as a customer. I’ll be coming back and recommending this to friends and family. Once again Thanks for delivering medicine with in 24 hours which help my wife to start treatment on time. "

- Mr. Sanjay More

"I’ve been using this medicine delivery service for a few months now, and I couldn’t be happier. The ordering process is simple and user-friendly, and the delivery is always prompt and reliable. I especially appreciate the timely updates, which help me stay on track with my prescriptions. The coordinator team is responsive and genuinely helpful, always ready to answer questions or resolve any issues. The packaging is secure, and the medicines always arrive in perfect condition. This service has made managing my health so much easier and stress-free. Highly recommended for anyone looking for convenience, reliability, and great customer care! "

- Mr. Nilesh Patankar

"I’m really impressed with the level of service. From placing the order to receiving the medicines, everything is smooth and hassle-free. The coordinator even called several times for updates my package. It’s rare to find such thoughtful service these days!"

- Mr. Mohit Vishwakarma

About us

We're a dedicated team of medicine access experts, doctors and pharmacists. We come from all over the world. And we've lost family and friends who could not get the medicine they needed because they lived in the wrong country.

Our mission is to get everyone the right treatment at the right time. Wherever you live. Because you should not suffer or die if a treatment that could help you exists somewhere.

Learn more ›

If you have any questions or need help, we're a phone call away. Our team is available from Monday to Friday between 9 a.m and 6 p.m CET

We usually respond to emails within 24 working hours

Call +919967979080
Email [email protected]

Worldwide Delivery

Afghanistan, Albania, Algeria, American Samoa, Angola, Anguilla, Antarctica, Antigua & Barbuda, Armenia, Aruba, Australia, Austria, Azerbaijan, Bahamas, Bahrain, Bangladesh, Barbados, Belarus, Belgium, Belize, Benin, Bermuda, Bhutan, Bolivia, Bosnia & Herzegovina, Botswana, Bouvet Island, Brazil, British Indian Ocean Territory, British Virgin Islands, Brunei, Bulgaria, Burkina Faso, Burundi, Cambodia, Cameroon, Canada, Cape Verde, Cayman Islands, Central African Republic, Chad, Chile, China, Christmas Island, Cocos (Keeling) Islands, Colombia, Comoros, Congo - Brazzaville, Congo - Kinshasa, Cook Islands, Costa Rica, Croatia, Cuba, Cyprus, Czechia, Côte d'Ivoire, Denmark, Djibouti, Dominica, Dominican Republic, Ecuador, Egypt, El Salvador, Equatorial Guinea, Eritrea, Estonia, Eswatini, Ethiopia, Falkland Islands, Faroe Islands, Fiji, Finland, France, French Guiana, French Polynesia, French Southern Territories, Gabon, Gambia, Georgia, Germany, Ghana, Gibraltar, Greece, Greenland, Grenada, Guadeloupe, Guam, Guatemala, Guernsey, Guinea, Guinea-Bissau, Guyana, Haiti, Heard & McDonald Islands, Honduras, Hong Kong SAR China, Hungary, Iceland, India, Indonesia, Iran, Iraq, Ireland, Isle of Man, Israel, Italy, Jamaica, Japan, Jersey, Jordan, Kazakhstan, Kenya, Kiribati, Kuwait, Kyrgyzstan, Laos, Latvia, Lebanon, Lesotho, Liberia, Libya, Liechtenstein, Lithuania, Luxembourg, Macao SAR China, Madagascar, Malawi, Malaysia, Maldives, Mali, Malta, Marshall Islands, Martinique, Mauritania, Mauritius, Mayotte, Mexico, Micronesia, Moldova, Monaco, Mongolia, Montenegro, Montserrat, Morocco, Mozambique, Myanmar (Burma), Namibia, Nauru, Nepal, Netherlands, New Caledonia, New Zealand, Nicaragua, Niger, Nigeria, Niue, Norfolk Island, North Korea, North Macedonia, Northern Mariana Islands, Norway, Oman, Pakistan, Palau, Palestinian Territories, Panama, Papua New Guinea, Paraguay, Peru, Philippines, Pitcairn Islands, Poland, Portugal, Qatar, Romania, Russia, Rwanda, Réunion, Saint Barthélemy, Samoa, San Marino, Saudi Arabia, Senegal, Serbia, Seychelles, Sierra Leone, Singapore, Slovakia, Slovenia, Solomon Islands, Somalia, South Africa, South Georgia & South Sandwich Islands, South Korea, Spain, Sri Lanka, St. Helena, St. Kitts & Nevis, St. Lucia, St. Martin, St. Pierre & Miquelon, St. Vincent & Grenadines, Sudan, Suriname, Svalbard & Jan Mayen, Sweden, Switzerland, Syria, São Tomé & Príncipe, Taiwan, Province of China, Tajikistan, Tanzania, Thailand, Timor-Leste, Togo, Tokelau, Tonga, Trinidad & Tobago, Tunisia, Turkey, Turkmenistan, Turks & Caicos Islands, Tuvalu, U.S. Outlying Islands, U.S. Virgin Islands, Uganda, Ukraine, United Arab Emirates, United Kingdom, United States, Uruguay, Uzbekistan, Vanuatu, Vatican City, Venezuela, Vietnam, Wallis & Futuna, Western Sahara, Yemen, Zambia, Zimbabwe, Åland Islands

Disclaimer

All trademarks, logos, brand names, and product names appearing on this website are the property of their respective owners. 247qualitymeds.com does not claim any ownership or affiliation with these trademarks or brands. They are used solely for informational and reference purposes to help users identify products and understand their intended use. The presence of any trademark or brand name on this website does not imply endorsement, sponsorship, or association with 247qualitymeds.com in any form.