Dantrolene

Dantrolene Capsules and Injection price and availability in India
Generic Name/API:Dantrolene
Packaging:Dantrium - 1 box contains 12 or 36 vials. For capsules: 1 bottle contains 100 hard capsules, Revonto - 1 box contains 1 vial, Ryanodex - 1box contains 1 vial
Storage:Dantrium: 15°C - 30°C (Capsule, IV) Revonto: 20 °C to 25 °C Ryanodex: 20 °C to 25 °C
Dosage:For dosage information, please check the General Information section.
Strength:Dantrium: Oral capsules: 25 mg, 50 mg, 100 mg. Injectable form: 20 mg/vial (IV). Revonto Injectable form: 20 mg/vial of Dantrolene sodium is available for reconstitution. Ryanodex Injectable form: 250 mg/vial of lyophilized powder of Dantrolene sodium is available in a single dose vial for reconstitution.
Indication:A muscle relaxant medication used to treat muscle spasms and rigidity associated with certain medical conditions, including malignant hyperthermia and neuroleptic malignant syndrome.

1. Dantrium

Dantrium is primarily used to treat spasticity associated with conditions like cerebral palsy, multiple sclerosis, and stroke. It is also a critical treatment for malignant hyperthermia (MH), a rare, life-threatening condition that can occur during surgery, particularly after the administration of certain anesthetics.

  • Available as oral capsules (25 mg, 50 mg, and 100 mg) and injectable form (20 mg/vial).

2. Revonto

Revonto is another Dantrolene sodium product, specifically used in the IV form for the emergency treatment of malignant hyperthermia. It is known for being rapid-acting and is often used in clinical settings where a quick response is needed. Revonto is more concentrated than other injectable forms, requiring a smaller volume for administration.

  • Available as an injectable solution (20 mg/vial).

3. Ryanodex

Ryanodex is another injectable Dantrolene sodium product, designed specifically for the treatment of malignant hyperthermia. It is a highly concentrated formulation, requiring only a small volume of fluid for dosing, which can be especially important during an MH crisis when minimizing fluid volume is crucial.

  • Available as an injectable (250 mg/vial).

Strength: 

Dantrium: 

  • Oral capsules: 25 mg, 50 mg, 100 mg.
  • Injectable form: 20 mg/vial (IV).

Revonto

  • Injectable form: 20 mg/vial of Dantrolene sodium is available for reconstitution. 

Ryanodex

  • Injectable form: 250 mg/vial of lyophilized powder of Dantrolene sodium is available in a single dose vial for reconstitution. 

Dosage: 

Medication  Dosage 
Dantrium  2.5 mg/kg IV (repeat as necessary up to 10 mg/kg)
Oral: Start at 25 mg/day (increase to 400 mg/day for spasticity)
Revonto  2.5 mg/kg IV (repeat as necessary, smaller volume, more rapid)
Ryanodex 2.5 mg/kg IV (repeat as necessary, concentrated form)

Side effects

  • Diarrhea
  • Dizziness
  • Drowsiness
  • Skin reactions on sun-exposed areas
  • Unusual weakness or fatigue

Adverse reaction:

  • Liver toxicity (potentially fatal).
  • Muscle weakness and respiratory issues.
  • Cardiovascular effects such as arrhythmias or hypotension.
  • Gastrointestinal discomfort (nausea, vomiting).

Storage: 

  • Dantrium: 15°C – 30°C (Capsule, IV)
  • Revonto: 20 °C to 25 °C
  • Ryanodex: 20 °C to 25 °C
  • Hepatotoxicity is a major concern, and liver function should be closely monitored.
  • Respiratory depression and cardiovascular instability can occur, so be cautious in patients with respiratory or heart conditions.
  • Monitor for muscle weakness and avoid it in patients with pre-existing muscle or neuromuscular disorders.
  • Elderly patients may be more vulnerable to side effects.
  • All three medications are Category C, meaning they should only be used during pregnancy if the benefits outweigh the risks.

 

Dantrolene Named Patient Program in India

FAQ

Dantrolene is used to treat:

  • Malignant hyperthermia (MH) — a rare but life-threatening reaction to certain anesthesia drugs.
  • Chronic spasticity due to conditions like spinal cord injury, stroke, cerebral palsy, or multiple sclerosis (only Dantrium oral formulation is used for this).

Yes, Dantrolene can be used in pediatric patients in the treatment of malignant hyperthermia. Dosing varies by weight and formulation.

Dantrolene is classified as Pregnancy Category C. It should only be used if the potential benefit justifies the potential risk to the fetus.

Dantrium is the brand name for Dantrolene Sodium, available in oral capsule and injectable form. The oral form is used for chronic spasticity, while the injectable is for acute malignant hyperthermia treatment.

Revonto is a lyophilized powder form of Dantrolene Sodium used for rapid IV reconstitution and administration during malignant hyperthermia crises.

Ryanodex is a highly concentrated formulation of Dantrolene Sodium for injection. It allows for rapid administration with fewer vials during a malignant hyperthermia emergency.

While selecting a supplier, we essentially ensure that the supplier holds a valid Good Distribution Practice (GDP) certification and possesses a valid operating license. These credentials confirm the supplier’s adherence to international standards for the proper distribution of medicinal products.

The cost of Dantrium, Revonto, Ryanodex (Dantrolene Sodium) in India varies as it is not always locally stocked and often must be imported. Supplier availability, import charges and currency fluctuations affect the final price. For the latest cost details, contact 24/7QualityMeds at +91 9967979080.

To buy Dantrium, Revonto, Ryanodex (Dantrolene Sodium) injection in India at a genuine price, contact 24/7QualityMeds. We assist with prescription/medical report verification, legal import process, certified supplier sourcing and ensure reliable delivery.

Related products